Mechanism of premature hair loss

Mechanism of premature hair loss

 

There is a difference between the mechanisms of premature hair loss or pattern baldness according to the gender difference. The Androgenetic hair loss in men is called male pattern baldness.

Mechanism of premature hair loss

For example, men's baldness is caused by the contact of androgen receptors in hair follicles with DHT (dihydrotesterone) enzymes. It is produced from DHT-5-alpha reductase type I and II.

For example, women baldness involves additional factors, such as the concentration of Cytochrome P-450-aromatase around hair follicles, together with the distribution of androgen receptor proteins in and around hair follicles.

Women, the DHT (dihydrotestosterone) are produced in reaction to dehydroepiandrosterone (DHEA) from the adrenal glands, together with the alpha 5 reductase and hydroxysteroid hydrogenase isomerase enzymes.

The cytochrome enzyme metabolizes androgens to estrogens, and changes in the ratio of estrogens and androgens to the estrogen level is high is hard to prevent the effects of androgens.

This physiological response, the difference in pattern baldness in men and women

Androgenetic mechanism of action men and women

Different concentrations of androgen metabolizing enzymes and androgen receptors are found in hair follicles of women when compared to men. The concentration of Cytochrome P-450-aromatase in frontal hair follicles six times higher in men compared to women when the frontal hair follicles. This concentration helps to maintain their front-line women's and men began to loose hair.

Women also have about 3 times less than the alpha-5-reductase type I or type II enzyme in frontal hair follicles compared to men. In contrast, androgen receptor content of the frontal hair follicles of men and 40% more hair follicles when compared with women who have hair loss in men is more evident.

Although there are differences in the mechanisms of premature hair loss in men and women, and treatment and rehabilitation procedures are the same: hair loss treatment for men and women are different, according to the intensity of hair loss.

If you are suffering from premature hair loss or baldness, for example, I have to thoroughly learn a little research before you consult a physician for treatment, hair treatment and rehabilitation medicine.

Role of genetics in premature hair loss

The scientific name for the genetic tendency for hair loss or pattern baldness is Androgenetic Alopecia, the main cause of premature hair loss in 95% of men and women in the modern world, it is premature hair loss is seldom noticed. In addition to genetic predisposition, there are a number of other causes such side effects hair loss medication, radiation, pregnancy, age, or even improper hair care. You should carefully study the causes of hair loss and find out yourself.

Role of genetics in premature hair loss

Premature hair loss

Among other important reasons for hair loss is hereditary or Genetics play an important role. In fact, genetics is the prime cause of premature hair loss or pattern baldness is genetic in this standard by name, as "an example of male baldness", but also the most common form of hair loss or baldness in women, the two genders for baldness is Androgenetic Alopecia, scientific name disease.

As an example of baldness that men and women, there is increased hair loss, as more and more hair thins, and begins to telogen (resting) phase, instead of remaining in the anagen (growing) phase. Finally, the degree of hair loss is so severe, that manifesting itself in the form of baldness.

Physiology of androgenetic hair loss

Androgenetic hair loss is the main factor of 5 alpha reductase enzymes. There are two types of these enzymes, 5 alpha-reductase type I is located in the sebaceous glands, epidermal and follicular keratinocytes, dermal papilla cells and sweat glands. 5 a reductase II isoenzyme are located mainly in the root sheaths of the scalp.

Both types I and type II isoenzymes convert to testosterone, the male hormone into dihydrotestosterone (DHT), the most important, that stimulates androgen androgenetic pattern hair loss or balding. DHT attacks the hair follicles are genetically sensitive to frontal to occipital hair follicles, which are seen from the back of the scalp. It damages the normal density and eventually leads to shedding.

Androgen - sensitivity hair follicles

This is due to genetic reasons, that a certain part of the scalp hair follicles are androgen sensitive. It is after puberty, when the production of male hormones from the genetically sensitive hair follicles responds to male hormones and therefore leading to a pattern balding. Due to the action of DHT (the result of circulating androgens), and hair must be miniaturized and becomes more resistant to shedding.

Although DHT is the main cause of hair loss in men and women, the mechanism and causes of hair loss and male pattern balding in women is different.